Cross-coupling reaction
We utilize a range of cross-coupling reactions that make use of transition metals as catalysts. These include Suzuki-Miyaura coupling and organic boronic acid (ester) derivatives, as well as OLED (organic light-emitting diode) compounds.
1. Suzuki-Miyaura coupling
We have developed a new form of heterocyclic coupling making use of divalent paladium (Pd(II)/C) and triphenylphosphine.
This reaction is much more efficient than traditional Pd(0)/C, allowing for creating, among others, phenylpyridines.
![1. Suzuki-Miyaura coupling1](/dcms_media/image/goodskill_img01.jpg)
![1. Suzuki-Miyaura coupling2](/dcms_media/image/goodskill_img02.jpg)
Pictured is Prof. SUZUKI Akira, professor emeritus of Hokkaido University (2010 Nobel Prize in Chemistry)
![Akira Suzuki, professor emeritus of Hokkaido University (2010 Nobel Prize in Chemistry)](/dcms_media/image/goodskill_img03.jpg)
2. Organic boronate ester derivatives
Aromatic and heterocyclic boronic acid (ester) derivatives act as key intermediaries in Suzuki-Miyaura reactions, making them extremely useful compounds in biaryl compound synthesis.
Through boronic acid synthesis using aryllithium compounds and arylmagnesium compounds and direct boronic acid synthesis, we have established a synthetic technology for a wide range of boronic acid (ester) derivatives.
Boronic acid synthesis from lithium and magnesium compounds
We are equipped to provide clients with a range of boronic acid (esters), from lab scale on through to industrial scale.
Ultra low temperature (-60 degrees Celsius) reaction equipment is used for synthesis.
![Boronic acid synthesis from lithium and magnesium compounds1](/dcms_media/image/goodskill_img04.jpg)
![Boronic acid synthesis from lithium and magnesium compounds2](/dcms_media/image/goodskill_img05.jpg)
Reactions using Grignard reagents
Our firm manufactures and sells Grignard reagents of a very high purity. We also excel at complex reactions that make use of Grignard reagents and require dry and oxygen-free conditions, allowing us to synthesize a wide range of compounds. Below is a example for some reactions achieved using Grignard reagents.
![Reactions using Grignard reagents](/dcms_media/image/goodskill_img07.png)
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